I pull my '72 TW with an Expedition. Same truck, different trim. No problems to speak of.
The rear hatch easily clears the tanks and tongue jack.
Mine has the adjustable pedals so my wife finally enjoys driving a big SUV. Now if I could only get her to drive while towing.
The only quirk I can think of is that the EXPY has full rear axle air suspension. Check for airbags instead of leaf springs.
The ride height computer gives a level ride so the initial WD setup is a little more involved. Additionally the rear end squats down at times if the rear hatch is open. The computer thinks it's helping by lowering the deck to help you load your stuff. Sometimes it makes putting the WD bars on difficult.