The OP has two young children, both older than two, but still in an age that can have a meltdown once in a while.
My question would be this: what do you do at home? I suspect the answer is that there is more physical separation, and the children understand that they have to be quiet around the "office" area. As much as possible, can the rest of the family be outside, maybe at the beach, park, zoo, etc?
I know that there are several road-schooling families, in which one parent is working from the coach while the other one is teaching the children. You might want to ask this on the escapees forum or the rv-dreams forum.
David Lininger, kb0zke
Heartland mpg 181 (sold)
1993 Foretravel U300 (for sale)