Unfortunately, you haven’t posted enough information to offer a definite opinion, but if your present set-up has a 6 AWG circuit from your DC power source to your fuse panel, AND all your
12 volt DC loads (lights, water pump, etc.) get their power through that fuse panel, AND you don’t intend to add any additional DC loads from that fuse panel, then there’s no need to change your 6 AWG circuit powering that fuse panel to a thicker wire size.
In that situation, the only circuit that should need the heaviest gauge (2/0 or thicker) should be the circuit between your new Victron Multiplus and your
12 volt trailer battery (or batteries). If the length of that circuit is over about 10 feet, you should consider going to an even thicker AWG, because DC travels poorly over distance. You can find charts online that can help you calculate AWG for DC based on distance.