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Anything is POSSIBLE, but some things are easier than others to do. The bathroom is the hardest thing to move because you'll also have to relocate all the plumbing and at least the blackwater tank. If the subfloor is bad and you're going to have to replace it all anyway, it's not as much extra work since it's just a question of planning where to put things when you put it all back together. If the trailer is pretty solid, moving the bath would be a lot of extra work.
I personally would prefer a center bath, but our Argosy has the rear bath and we're OK with it after camping in it for a while. The bath is pretty small (probably the same size as you're Safari) and I wouldn't want to make it that much smaller, so it would just be taking up the same amount of space somewhere else.
Zero Gravitas ó 2017 Flying Cloud 26U | WBCCI# 15566
He has all of the virtues I dislike and none of the vices I admire. ó Sir Winston Churchill