Uh, no. That's not how fuses work.
The 250 volt part of the rating is the voltage the fuse will interrupt safely. It has to do with arc safety.
The current is the same for any voltage rating.
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Rich, KE4GNK/AE, Overkill Engineering Dept.
'The Silver HamShack' ('07 International 22FB CCD 75th Anniversary)
Multiple Yaesu Ham Radios inside and many antennae sprouting from roof, ProPride hitch, Prodigy P2 controller.
2012 shortbed CrewMax 4x4 Toyota Tacoma TV with more antennae on it.