This summer ran into tow vehicle problems (traveling alone) about 2,500 miles from home. I was able to rent a Ford F150 truck from Enterprise that was set up to tow, switched my hitch & weight distribution bars over to it and towed just fine a couple hundred miles to my sister's house while I waited for my tow vehicle to be fixed. No problems - but it wasn't cheap, about $200+ per day - so I just rented it to get where I was going, then turned it in and sat for a week. I think the keys to my success were:
1) I am familiar with towing my Airstream
2) I have towed this & different trailers with several different tow vehicles before
3) I know my hitch / weight distribution hook-ups
4) the truck was new and had a built-in brake controller
5) it was a easy stretch of the drive - not challenging in any way
I would not have felt as comfortable if it was my first time towing with "everything" new and the nerves/excitement of retrieving a new trailer.