For starters it's going to be a heckuva lot heavier than the frame was designed for. A/S is a semi-monococque design where the frame, walls and subfloor -- tied together -- provides it's strength. The frame, alone, is not all that strong, nor is the quality of steel "high strength" (as I understand it). I would research "tail droop" and "elephant ear repair" on this forum as a start. This thread
is a beginning.
recently showed some custom builds that weighed around 13K IIRC, or, about 1.5 to 2X the expected weight of an A/S TT that size due to unique requirements. You've your work cut out in this regard as they will also be unique. All other considerations are subservient to this. problem of weight, thus strength.
If the thought of an enclosed support trailer is already in mind, then expand on it, IMO. I am not
saying it cannot be done or should not be done, it has and will continue to be. But forewarned is forearmed as budgets are created. Search also "mobile food". Here's one
And here's a thread
from another site where truck campers, fifth wheels and travel trailers are mounted on goose-neck flatbed trailers in order to accommodate other vehicles and gear. See the "mobile mansion" thread for a representative build.