Welcome to the Forums.
I think your question is impossible to really answer with any accuracy with out knowing more about your wife.
As a general statement, there is nothing about being female that would preclude her from towing an airstream or setting one up.
The question is, what kind of female is she?. If she doesn't like to get her hands dirty. She will. Has she ever towed anything before? Is she a good driver? Is she mechanical, does she like a challenge, do either of you have any experience with this sort of thing?
Bottom line, people of all ages and genders can learn anything they set their mind to, all things being equal. Nothing about rocket science really going on here, but I would say a smidge of mechanical aptitude, at times a wee bit of muscle, and a damn good driving acumen are handy.
My advice would be to rent an RV ( any type) first,
and see how you like it, and determine if it is something that is manageable before buying one. Good luck.