I'm not saying that you can't do it, but know that in all likelihood, there will have to be some modifying to the frame where it attaches. As well, the wheels also will need alignment.
I took the easy way out - I had new running gear installed at JC. In doing it that way, I was able to get heavier axles (went from 4,000 lb axles to 4,500 lbs, thereby increasing the combined axles weight rating from 8,000 lbs to 9,000 lbs. JC charged me $1,500 per axle (axle with hub & brakes, labor to install and align, and taxes) all in. You can also choose the Nev-R-Lube hubs. The job took them almost one day.
1987 Excella 32-foot
1999 Dodge Ram 2500HD Diesel