The TPM system would probably be the best thing at this time.
Run-flat tires are not currently available in any size approaching what we would need for our coaches, not to mention the correct weight rating. If they were available, they would most likely cost around $1000 for a pair. For that much money, I will check my tires every time I stop for gas or food...
Meddle not in the affairs of dragons, for you are crunchy, and taste good with ketchup.