I just came back from a long weekend in Springfield, MO (not towing). My recommendation is that you check road construction often (I use Google Maps traffic a lot).
Lots of work is happening on Interstate 44 particularly west of St. Louis around Villa Ridge and Washington, MO exits. Also check Interstate 55 construction on the Illinois side particularly around Troy, IL through to Litchfield and Divernon exits. The work appears to be resurfacing with major ramp repairs and work. In some cases, ramps are closed entirely.
Heading east back to Bloomington, I took the Jefferson Barracks bridge across the river at St. Louis. Near Troy, I got off on Interstate 70 to US 51 at Vandalia, IL to avoid construction on Interstate 55 between Troy and Litchfield, IL. Crossing the Jefferson Barracks heading east, they did have at least one lane of the bridge closed. I figured that was better than dealing with construction on Interstate 64 through St. Louis.
The construction and different routes I took added about an hour to my normal drive time to/from Springfield, MO. The lady at the Tourist Info counter at Silver Lake Rest Area on Interstate 70 said someone had just told her they spent 2.5 hours waiting in construction zones on Interstate 55. Lots of it has to do with time of day and the fact that several lanes of traffic are channeled into one -- and some folks don't get over to the one lane till the last minute.