I would prefer to be beamed to places far away, but while waiting for that technology to be installed, interstates get me across country quickly. I have this vague memory (many memories are vague these days) that interstates are safer than other highways too. Passing is generally easier—farm trucks, lost people, 18 wheelers, and those slow RV's all can hold you up a lot when you need to get somewhere on two laners. Scenery isn't too noticeable when stuck behind 5 vehicles going 35.
Two lane blacktop is usually preferable for touring, but places to tour can be far between. Our trips are combinations of both.
In the west where there are fewer interstates, 2 laners are the only way to go a lot of the time anyway.
I agree with the statements on the first link 2air posted that the 2 laners have better pavement than interstates in recent years. Federal maintenance money for interstates has been limited in recent decades—federal gas taxes haven't kept up with inflation—and we pay the price for that in damage to vehicles.