I recommend taking I-275 around the east. I-275 to the west would also work but is longer.
I-75 near downtown Cincinnati is undergoing a complex, multiyear construction project that is adjusting alignments to ease curves, altering various interchanges and exits, and maybe doing a bit of widening in places. As this is all going on, lanes can be temporarily shifted or closed, exits get temporarily (or in some cases permanently) closed, and sometimes there are night or weekend full closures when they're working on overpasses. This is going to continue for a couple more years, IIRC.
At some point, just beyond the current construction zone, they'll be replacing the Brent Spence Bridge that currently carries I-71 and I-75 over the Ohio River. Since Ohio, Kentucky, and possibly the Feds will have to come to an agreement on that, don't hold your breath, but it has to be done eventually.