We just came back from a most awesome vacation, having spent most of it in Damascus, VA - highly recommend!
Damascus is on the southern part of VA, close to the TN line and not far from NC - maybe a 2 hour drive north of Asheville, NC. We rented bikes and road down the VA Creeper - a 15-20 mile bike ride (downhill) on an old rails-to-trails conversion. The entire ride is nothing less than spectacular - the trail runs parallel to a gorgeous river most of the way.
The Appalachian Trail runs right through the center of Damascus, so we used the opportunity to do a little hiking on the AT, and we look forward to going back better prepared to explore more of the trail - maybe do an overnight or two.
We camped with our Airstream in a tiny 5-6 site campground right in the center of town (I'll find the name, but Russell the owner was a hoot - and a big help); full hookups, and right on a bubbling river.
Check it out!
2008 Airstream 27FB International Ocean Breeze
2014 Ford F250 King Ranch 4X4 w/6.7L Diesel, Hensley Hitch