We went out West with a group from our "old car" club, with the destination being Pueblo, CO. On the way we drove parts of Rt. 66, which was a thrill for us (but, you need to know that it is not "complete" any longer -- you need to go off and on Rt. 66). We saw so much of our country, it was great.
We had planned to go to Sedona, AZ after Sante Fe, NM, but our rear end went out of our 1936 Ford, so we had a two-day delay for repairs to that -- all was well in the end though. We were fortunate we were able to limp into Sante Fe, so we spent the two extra days there -- fantastic!! I'd say, don't miss it! We stayed in the famous hotel right downtown (no TT then, just our old cars), and walked all over the downtown area. The Indians set up along one side, I can't remember for sure, but I think it is a downtown square and they use one side for selling fantastic jewelry. Be warned though, it's difficult to walk away empty handed (and you can get them down on the pricing, somewhat).
One place I would say to not miss going to when in Sante Fe, NM is "Tia Sophia's", it's a restaurant which has the most delicious food. I believe I had the most mouth watering blueberry pancakes I've ever had in my entire life; I'd love to have the recipe! Everyone else in our group loved their breakfast also.
Pueblo, CO was where we were headed for the NSRA car show, so our time there was spent at the show and I can't really advise about what to see and do there, except there was a delicious Mexican restaurant there that was to die for, I think the name of it was "Horjes", my spelling is probably off. It gets very busy there but it is well worth the wait, much, much better than anything we have here in Ohio.
Have fun and I'm jealous if you get to either of those restaurants.
Actually, if we make it to Albequerque, NM, October, 2011, for the Balloon Fest, we plan to go at least to Sante Fe, NM and Sedona, AZ (as well as some other touring around).