We are happy with our 22 for a lot of reasons.
Large bed is very comfortable.
Lots of windows that open for excellent cross ventilation.
Narrow width makes towing and parking a bit easier.
Kitchen counter spaces is amazing. Let's face it, the 22 probably has more kitchen counter space than anything besides the 20, until you get to the 27.
Storage is very good. I really wanted a place in the bathroom to keep toiletries and towels, and a place in the kitchen for dishes and silver ware and bar ware.
Under the dinette the storage is much better than a lot of the front dinettes, since there is no drawer taking up real estate.
Our booze, ice bucket, (diva here don't you know!), grill, pots and pans, and fan and extension cord all fit under the dinette.
Under the bed we have the bag chairs, coleman stove, side table for outside, baby gate for the dog, and 2 of the airstream bins. One empty bin (will probably put extra tools there for long trips) Other has extra towels and TP.
Then we keep the power cord and surge protector in the closet, and the hoses and hand tools in the outside storage compartment.
I was pretty adamant about not having to keep much in the tow vehicle.
I like the look of things put away to minimize the clutter. It would get on my last nerve to have things out and everywhere.
Our clothes all fit in the closet.
The bathroom is large enough to change clothes in or towel off after a shower.
So once we set up camp, in our TV is only the stuff that lives outside: large cooler, bikes, lantern, smokey joe weber grill. All our clothes and food fit inside and put away in the trailer. I have a vintage wooden pic nic basket for chips, crackers, etc. A soft side bag cooler that fits under the dinette for transit of things that I don't put in the "wet" cooler like fruit, cheese, butter, lettuce, sandwiches, etc.
Condiments fit in a bin under the sink, as do utensils and a cutting board and linens and cleaning items.
We we keep beverages and any meats in the Yeti cooler outside. (thanks to Protagonist's post last winter on the Yeti)
We can't leave from home, so we can't pre-cool the fridge. So we need a good cooler until the fridge cools down.
I also like that the 22 was one of the most affordable AS, and we were fortunate to find a 2015 used at a dealer. So someone else who wanted a larger unit got to take the depreciation hit and we got a trailer that was 9 months old and didn't have to pay new.
I would think that for 2 people that this would be large enough to camp on multi week trips. But if you are looking for more of a second-home, then this would be not the best option, and then I would think a 27-28 would be better.