Well, being on the road for a year, I would say one of the biggest negatives is the lack of storage space. Consider removing the seat behind the driver and install a custom cabinet. That's really the main disadvantage and you will typically not be lounging around inside. We travel as 2-adults & 2-teens and do a lot of hiking so we're not spending a lot of daylight hours inside unless we're on the road.
That said, I consider Sprinter Class MH a huge advantage when when driving on roads like Glacier NP Going To The Sun Road, southern entrance to Sequoia NP, the eastern entrance to Zion NP, St. Augustine drive-on beach, etc. We've been on lots of roads where a larger unit would either not be allowed or would be doing 3-point turns at every switchback. Then there's the NP/SP campgrounds. Being a Class B, we're typically allowed in tent-only spots that allow cars. Many of those campgrounds have limited RV spots and once you're over 24/26 feet your choices become limited which is why many larger rigs tow a car to sightsee from the commercial CG outside the Parks. We also don't usually stay in one spot more than 3-days so mobility is a higher priority. The on road manners of the 3500 chassis is superior to any SRW variant.
I looked at all the Sprinter based Class B RV's, (and used to own a Roadtrek), and found the AS to be the best fit & finish.
2009 Airstream Interstate