Hello,
We have driven a lot of this route at least from Brookings to Lincoln City pulling our Bambi... lots of folks travel this route with big rigs. Shouldn't be a problem pulling a 25 footer. The very worst part of Route 1 is in California just north of San Francisco... very slow and lots of tight corners in this section.
When driving in Oregon on route one... if you will be traveling during the summer months be aware it is a highly sought after vacation area and traffic is dense... one RV and motorhome after another. And, remember, it rains a lot (all year) in Oregon! We have usually made this these trips in the rain ~ so I suggest avoiding driving at night as the roads are winding. There are some areas that might give some folks "food for thought" but they are in areas where you can't drive fast, so you should be okay. Because of the number of turns and twists in the road, the traffic, etc. calculate on doubling your time for travel while transiting Hwy 1.
The Oregon Coast is awesome and worth every minute. See it in the daytime, take your time and enjoy. There are many, many campsites along the coast. However, in summer they fill quickly many times. The Oregon State Campgrounds are awesome, and many have reservations. Check out the state website, then click on parks with campgrounds!
State of Oregon: Oregon Parks and Recreation Department: State Parks
Have fun!
Mrs. NorCal Bambi traveling in S Tardis ~ from the Great State of Jefferson